Preheat oven to 425°F (220°C).
In a large bowl, whisk together olive oil, balsamic vinegar, Italian seasoning, minced garlic, salt, and pepper to make the vinaigrette.
Add the quartered Brussels sprouts to the bowl and toss thoroughly to coat with vinaigrette.
Arrange the Brussels sprouts on a parchment-lined baking sheet in a single layer.
Roast in the oven for 15-20 minutes, stirring halfway, until crispy and tender.
Remove from oven and transfer to a serving dish. Top with fresh pomegranate arils for a burst of color and flavor.
(Optional) Sprinkle freshly grated Parmesan Reggiano over the top for added richness.
Serve immediately and enjoy this vibrant, healthy fall side dish!